Your Guide to Genetics & Nutrition
Representing over 500 hours of research, the Gene Food Guide to Nutrigenomics was built to catalogue genetic markers that can be influenced by nutrition. Before building the personalized nutrition algorithm we now offer to consumers and health systems, our research team, led by geneticist Dr. Aaron Gardner compiled an exhaustive list of the scientific research in the field of nutrigenomics. Applicable genes were scored based on the state of the scientific evidence with a Science Grade and published, with citations, in the guide. Genes that had sufficient evidence were included in our algorithm and weighted based on strength of research. The guide is updated regularly as new research emerges.
Genes
90+
SNPs
170+
Citations
500+
| Gene | Normal Function | SNP ID | Major Allele | Minor Allele | |
|---|---|---|---|---|---|
| NOS3 | NOS3 is an enzyme responsible for synthesizing nitric oxide, which is important in many biological processes, especially cardiac function. | G51-898A | a | g | |
| T894G | g | t | |||
| A-52+1009T | t | a | |||
| NQO1 | NQO1 is an enzyme with an antioxidant role. | C559T | c | t | |
| PCSK9 | The PCSK9 protein controls the number of low-density lipoprotein (LDL) receptors on the surface of cells. LDL receptors are critical for regulating blood cholesterol levels. The PCSK9 protein waylays LDL receptors after they transport cholesterol into cells, leading to their destruction. This prevents LDL receptors being recirculated back to the cell surface, which means fewer receptors overall and more cholesterol remaining in the bloodstream. | E670G | a | g | |
| V474I | a | g | |||
| R46L | g | t | |||
| L253F | c | t | |||
| G1327A | g | a | |||
| C2037A | c | a | |||
| PEMT | PEMT is an enzyme which generates phosphatidylcholine, a key component of cell membranes. | G523A | g | a | |
| PPARA | PPAR-alpha regulates the expression of genes involved in multiple steps of lipid metabolism, glucose metabolism, and energy homeostasis, and in addition it plays a role in the inflammatory process and vascular function. | L162V | c | g | |
| PPARG |
PPARG is a receptor protein mainly expressed in adipose tissue that regulates glucose metabolsim. |
68777C>G | c | g | |
| SHMT1 | SHMT1 is an enzyme of the one carbon cycle, converting folate into a variety of other cellular products. | C1420T | c | t | |
| SLC19A1 | SLC19A1 is a folate transporter. | A80G | g | a | |
| SLC2A14 | SLC2A14 is a transporter protein which shuttles glucose into cells. | A8025266G | a | g | |
| C8008132A | c | a | |||
| C8023530T | c | t | |||
| SOD2 | SOD2 is an antioxidant enzyme found specifically in the mitochondria of cells. | T47C, A16V | c | t | |
| SOD3 | SOD3 is an antioxidant enzyme which is secreted by cells in the brain, lungs and other tissues at high risk of oxidative damage. | C691G | c | g | |
| SULT1A1 | SULT1A1 is an enzyme which targets hormones, neurotransmitters for degradation. | G638A | c | t | |
| TCF7L2 |
TCF7L2 is a transcription factor which regulates a wide variety of cellular processes including synthesis of glucagon in the pancreas. |
53341C>T | c | t | |
| TERT | TERT forms part of the telomerase enzyme which is responsible for maintaining chromosome telomeres in selected cells. | G1574-3777T | g | t | |
| TRPM6 | TRPM6 is a channel protein which traffics magnesium into cells in the kidney. | A33+2944G | a | g | |
| VDR | VDR is the receptor for vitamin D, its main function is to regulate calcium uptake from the gut into the bloodstream. | BsmI | g | a | |
| FokI | c | t | |||
| TaqI | t | c | |||
| ApaI | t | g |