NOS3

Tetrahydrobiopterin (BH4 or THB), sometimes known as sapropterin is one of three co-factors required by NOS3 to function efficiently ⁷. As the risk ‘G’ allele of G51-898A is hypothesized to lead to reduced NOS3 activity, supplementation with BH4 may prove beneficial to those carrying the risk allele with elevated blood pressure or who are at cardiovascular risk.

Vitamin B2 is one of three co-factors required by NOS3 to function correctly ⁸. With the risk ‘G’ allele of G51-898A proposed to be associated with reduced NOS3 activity, supplementation with vitamin B2 may prove beneficial those with elevated blood pressure or who are at cardiovascular risk.

Iron is one of three co-factors required by NOS3 in order to function ⁹. Iron supplementation may benefit those at cardiovascular risk, especially those carrying the risk ‘G’ allele of G51-898A. However, care should be taken with iron supplementation as excessively dietary iron is associated with increased risk of coronary heart disease ¹⁰.

Nattokinase is an enzyme which is extracted and purified from a Japanese food called nattō, which is made from fermented soybeans.

Nattokinase is secreted by the bacteria involved in the fermentation process and has a very strong ability to break down fibrin blood clots ¹¹. A beneficial effect on blood pressure ¹², and general cardiovascular health has been described ¹³. Therefore, supplementation may benefit those carrying the risk ‘G’ allele of G51-898A, especially those with elevated blood pressure or cardiovascular risk.

Coenzyme Q10 (CQ10) is a naturally occurring coenzyme with numerous health benefits. A positive effect was seen in those with elevated blood pressure ¹⁴, but no effect was seen in healthy controls ¹⁵. Therefore, supplementation may only be recommended for those with elevated blood pressure who also carry the risk ‘G’ allele of G51-898A.

Bergamot orange is a sour citrus fruit similar in size to an orange and is typically grown only in Mediterranean areas.

Bergamot oranges are frequently processed into oil for a variety of uses, such as providing citrus notes to perfumes and in skin creams. More recently positive health effects have been described. Melitidin and brutieridin are two flavone molecules found only in Bergamot oranges which exhibit statin (blood pressure lowering) ¹⁹ like properties, and also lower lipids present in the blood ²⁰.

As such supplementation may benefit those carrying the risk ‘G’ allele of G51-898A. which is associated with an increased cardiovascular risk and elevated blood pressure.

The impacts of a high sodium diet are well established ¹⁶. Therefore, in those carrying the risk ‘G’ allele of G51-898A which is associated with elevated blood pressure, a reduction in sodium intake to recommended levels should be considered.

Tetrahydrobiopterin (BH4 or THB), is one of three co-factors required by NOS3 to function correctly ⁷. The risk ‘T’ allele of T894G is hypothesized to lead to reduced NOS3 activity; therefore, supplementation with BH4 may provide benefit to those carrying the risk allele with elevated blood pressure or who are at cardiovascular risk.
Vitamin B2 Riboflavin phosphate
Vitamin B2 is a co-factor required by NOS3 to function correctly ⁸. With the risk ‘T’ allele of T894G proposed to be associated with reduced NOS3 activity, supplementation with vitamin B2 may prove beneficial those with elevated blood pressure or who are at cardiovascular risk.

Vitamin B2 is a co-factor required by NOS3 to function correctly ⁸. With the risk ‘T’ allele of T894G proposed to be associated with reduced NOS3 activity, supplementation with vitamin B2 may prove beneficial those with elevated blood pressure or who are at cardiovascular risk.

Iron is one of three co-factors required by NOS3 in order to function properly ⁹. Therefore, iron supplementation may benefit those at cardiovascular risk, especially those carrying the risk ‘T’ allele of T894G. However, care should be taken with iron supplementation as excessively dietary iron is associated with increased risk of coronary heart disease ¹⁰.

Nattokinase is an enzyme which is extracted and purified from the Japanese food nattō, which is made from fermented soybeans. Nattokinase, secreted by the bacteria involved in the fermentation process, breaks down fibrin containing blood clots ¹¹. Based on this clot-busting ability a beneficial effect on blood pressure ¹², and general cardiovascular health has been described ¹³. Supplementation may benefit those carrying the risk ‘T’ allele of T894G, especially those with elevated blood pressure or cardiovascular risk.

The naturally occurring coenzyme Q10 (CQ10) is associated with numerous health benefits. A positive effect was seen in those with elevated blood pressure ¹⁴, however, no effect was seen in healthy controls ¹⁵. Therefore, supplementation may only be recommended for those with elevated blood pressure who also carry the risk ‘T’ allele of T894G.

Omega-3 fatty acids demonstrate a protective effect against cardiovascular disease in those with an existing cardiovascular risk ¹⁸. In those carrying the risk ‘T’ allele of T894G, dietary supplementation with omega-3 fatty acids was shown to improve cardiovascular risk by reducing triacylglycerol levels in the blood ⁵.

The impacts of a high sodium diet are well established ¹⁶. Therefore, in those carrying the risk ‘T’ allele of T894G which is associated with elevated blood pressure, a reduction in sodium intake to recommended levels should be considered.

Tetrahydrobiopterin (BH4 or THB) is a co-factor required by NOS3 ⁷. The risk ‘A’ allele of A-52+1009T is hypothesized to lead to reduced NOS3 activity; therefore, supplementation with BH4 may prove beneficial to those carrying the risk allele with elevated blood pressure or with existing cardiovascular risk.

Vitamin B2 is one of three co-factors required by NOS3 to function properly ⁸. The risk ‘A’ allele of A-52+1009T is hypothesized to be associated with reduced NOS3 activity. Therefore, supplementation with vitamin B2 may prove beneficial those with elevated blood pressure or who are at cardiovascular risk.

Iron is a co-factor required by NOS3 in order to function correctly ⁹. Therefore, iron supplementation may benefit those at cardiovascular risk, especially those carrying the risk ‘A’ allele of A-52+1009T which is associated with elevated blood pressure. However, care should be taken with iron supplementation as excessively dietary iron is associated with increased risk of coronary heart disease ¹⁰.

The Japanese food nattō, which is made from fermented soybeans, is rich in the enzyme nattokinase. Secreted by the bacteria involved in the fermentation process, nattokinase breaks down fibrin containing blood clots ¹¹. Based on this ability a beneficial effect on blood pressure ¹², and general cardiovascular health has been described ¹³. Therefore, supplementation may benefit those carrying the risk ‘A’ allele of A-52+1009T, especially those with elevated blood pressure or cardiovascular risk.

Coenzyme Q10 (CQ10), a naturally occurring coenzyme with numerous health benefits, has been shown to have a positive effect in those with elevated blood pressure ¹⁴, however, no effect was seen in healthy controls ¹⁵. Therefore, supplementation may be recommended to those carrying the risk ‘A’ allele of A-52+1009T, who also display elevated blood pressure.

The impacts of a high sodium diet are well established ¹⁶. Therefore, in those carrying the risk ‘A’ allele of A-52+1009T which is associated with elevated blood pressure, a reduction in sodium intake to recommended levels should be considered.