M-R Dr. Gina Leisching Heart Health Genes PPARA PPAR-alpha regulates the expression of genes involved in multiple steps of lipid metabolism, glucose metabolism, and energy homeostasis, and in addition it plays a role in the inflammatory process and vascular function. Heart Health Genes MLXIPL A transcription factor that regulates glycolysis (an cycle of biochemical reactions generating energy from glucose) and lipid production, predominantly in the liver Heart Health Genes PCSK9 The PCSK9 protein controls the number of low-density lipoprotein (LDL) receptors on the surface of cells. LDL receptors are critical for regulating blood cholesterol levels. The PCSK9 protein waylays LDL receptors after they transport cholesterol into cells, leading to their destruction. This prevents LDL receptors being recirculated back to the cell surface, which means fewer receptors overall and more cholesterol remaining in the bloodstream. Gastrointestinal Genes MADD MADD is thought to regulate controlled cell death but is also implicated in other cellular events. Endocrine Genes MTR MTR is responsible for the regeneration of methionine from homocysteine. Heart Health Genes PPARG PPARG is a receptor protein mainly expressed in adipose tissue that regulates glucose metabolsim. Gastrointestinal Genes SLC2A14 SLC2A14 is a transporter protein which shuttles glucose into cells. Gastrointestinal Genes NOD2 NOD2 plays an important role in the immune system. Longevity Genes NQO1 NQO1 is an enzyme with an antioxidant role. Heart Health Genes NOS3 NOS3 is an enzyme responsible for synthesizing nitric oxide, which is important in many biological processes, especially cardiac function. Women's Health Genes MTHFD1 MTHFD1 is an enzyme is an enzyme involved in the conversion of dietary folate into a variety of key products. Gastrointestinal Genes MTRR MTRR is an enzyme which helps maintain methionine synthase function, a key component of the methionine cycle. 1 2 »
