ATP13A1
Sandeep Grover Recent work has shown that this protein uses energy (ATP) to extract and remove mitochondrial proteins from the endoplasmic reticulum. 1 SNPs in the vicinity of this gene, including those known to affect its expression, are associated with triglyceride levels. 2 However, the function of ATP13A1 in fatty acid metabolism is unknown.
| rsID Number | Major Allele | Minor Allele | Minor Allele Frequency (%) |
|---|---|---|---|
| rs141844019 | c | t | 1 |
Risk Description
The Gene x Environment genome-wide association study (GxE GWAS) for lipid levels with and without fish oil supplementation that detected this interaction effect 3 was high-powered and used a replication cohort, followed by a joint meta-analysis of both cohorts. Therefore, these results deserve our attention. However, it must be noted that interpreting GxE interaction effects such as this one can be tricky and the true phenomena behind them may sometimes be counterintuitive. 4 In addition, the mechanism through which this variant may affect triglyceride levels remains unknown. Therefore, acting on this association requires some caution.
Indirect Nutrients:*
| Ingredient | Active Ingredient | Effect |
|---|---|---|
| Fish Oil | Omega-3 |
Fish oil may help reduce triglyceride levels in the carriers of the major T allele of rs141844019 (TT or TC genotypes). |
Discuss this information with your doctor before taking any course of action.
Citations:
- McKenna MJ, Sim SI, Ordureau A, et al. The endoplasmic reticulum P5A-ATPase is a transmembrane helix dislocase. Science (New York, N.Y.). 2020 Sep;369(6511):eabc5809. DOI: 10.1126/science.abc5809.
- The OpenTargets platform https://platform.opentargets.org/target/ENSG00000105726
- Francis M, et al. Genome-wide association study of fish oil supplementation on lipid traits in 81,246 individuals reveals new gene-diet interaction loci. PLoS Genet. 2021 Mar 24;17(3):e1009431. doi: 10.1371/journal.pgen.1009431.
- Thompson WD. Effect modification and the limits of biological inference from epidemiologic data. J Clin Epidemiol. 1991;44(3):221-32. doi: 10.1016/0895-4356(91)90033-6.