APOC3
Sandeep Grover Apolipoprotein C3 (APOC3) is a protein primarily involved in lipid metabolism and the regulation of triglyceride levels in the bloodstream. APOC3 inhibits the activity of lipoprotein lipase, an enzyme responsible for breaking down triglycerides in circulating lipoproteins.
By inhibiting LPL, APOC3 reduces the clearance of triglyceride-rich particles, leading to elevated triglyceride levels in the blood. APOC3 also plays a crucial role in regulating the metabolism of various lipoproteins, including very-low-density lipoproteins (VLDL) and chylomicrons.
| rsID Number | Major Allele | Minor Allele | Minor Allele Frequency (%) |
|---|---|---|---|
| rs5128 | c | g | 10.7 |
Risk Description
Individuals with GC/GG genotypes and diabetes exhibit significantly higher levels of triglycerides (1.91 vs 1.62 (mmol/L)^2) (p=0.004), total cholesterol (4.67 vs 4.29 (mmol/L)^2) (p=0.003), and glucose (8.74 vs 7.91 (mmol/L)^3) (p=0.016) when compared to CC subjects. 1
Discuss this information with your doctor before taking any course of action.