KIAA1109
Sandeep Grover KIAA1109 is included in the Gene Food “Gluten Intolerance” panel. The gene can be found on the extended portion of chromosome 4, a location linked to increased risk for Celiac disease. The protein produced by this gene shares similarities with a protein in Chinese hamsters connected to the differentiation of spermatocytes and adipocytes. In mammals, this protein is believed to play a role in guiding the growth and differentiation of epithelial cells and the onset of tumors.
Genetic variants in the KIAA1109 gene are linked to an increased risk of Celiac disease, a disease that occurs when the immune system reacts to gluten present in wheat, barley, and rye, damaging the small intestine and hindering nutrient absorption. 1
| rsID Number | Major Allele | Minor Allele | Minor Allele Frequency (%) |
|---|---|---|---|
| rs13151961 | a | g | 15.4 |
Risk Description
In a genome-wide association study, individuals carrying the G allele of this variant have a 35% reduced risk of developing Celiac disease than those without the disease.
Carriers of rs13151961 comprise a relatively small percentage of the population, with most of us carrying the risk A allele for this marker. 1
Discuss this information with your doctor before taking any course of action.