FGFR1
FGFR1 is a receptor protein expressed in a very broad array of tissues, where it regulates a wide range of processes, including cell division, differentiation and metabolism. Its many roles include co-operation with the anti-aging and neuroprotective protein Klotho in the kidney 1. These proteins co-recruit a type of fibroblast growth factor known as FGF23, which regulates phosphate and calcium homeostasis 2.
| rsID Number | Major Allele | Minor Allele |
|---|---|---|
| rs881301 | t | c |
Risk Description
This variant does not affect the amino acid composition of the FGFR1 protein, but positively affects its expression. The minor C allele of this variant is associated with higher FGFR1 expression. The same allele also shows a strong association with lower levels of the circulating Klotho protein 3, which is thought to confer anti-aging and neuroprotective benefits 4, 5, 6. The mechanism of this effect may involve a competition between the FGFR1-bound and circulating Klotho.
Discuss this information with your doctor before taking any course of action.
Citations:
- https://www.nature.com/articles/s41571-024-00869-z
- https://www.nature.com/articles/s41569-023-00903-0
- https://academic.oup.com/hmg/article/31/5/792/6372546
- https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2020.00560/full
- https://academic.oup.com/biomedgerontology/article/66A/7/794/616322
- https://portlandpress.com/neuronalsignal/article/5/2/NS20200101/228755/Exploiting-the-neuroprotective-effects-of-klotho