CYP2R1

CYP2R1 is responsible for converting vitamin D, either from the diet or generated in the skin, into the circulating form calcifediol, which can in turn be converted into the bioactive form calcitriol. For those with the ‘G’ allele of T-1127C, which is associated with reduced levels of circulating vitamin D, calcifediol, supplementation with the bioactive form calcitriol may help ensure that appropriate vitamin D levels are maintained ensuring proper calcium uptake maintain bone health and ensuring normal cellular function. Additionally, given that the majority of us are vitamin D deficient anyway supplementation is to be recommended to ensure both healthy calcium uptake, and that the other cellular activates dependent on vitamin D can proceed normally ^8,9.

Iron is a cofactor for CYP2R1 and is required for it to function correctly. For those with the ‘G’ allele of A226-2810C, which is associated with reduced levels of circulating vitamin D, supplementation with iron may ensure that CYP2R1 is functioning maximally, although the importance of this SNP in bone health and other cellular functions is likely minor ¹⁰.

The main function of vitamin D binding to VDR is to ensure proper uptake of calcium from the gut. Whilst, calcium is not typically limited in the normal diet those pursuing a vegan, or dairy free diet may consider supplementation, especially if they carry the ‘G’ allele of T-1127C ¹¹.

There have been numerous observations that an increase in caffeine intake associates with poor bone health and a risk of developing osteoporosis. Caffeine is thought to promote the excretion of calcium in urine, whilst simultaneously preventing the production of new bone. Whilst there is an association with increased caffeine intake and poor bone health nothing specific has been described for those carrying the ‘G’ allele of T-1127C ¹².

CYP2R1 converts vitamin D, either from the diet or generated in the skin, into its circulating form calcifediol, which is in turn converted into the bioactive form calcitriol. For those with the ‘G’ allele of A226-2810C, which is associated with reduced levels of circulating vitamin D, calcifediol, supplementation with bioactive calcitriol may ensure that appropriate vitamin D levels are maintained to deliver proper calcium uptake, maintaining bone health and ensuring normal cellular function ¹⁴.

Although the ‘G’ allele of A226-2810C has not been associated with poor health outcomes; given that the majority of us are deficient in vitamin D, supplementation is usually to be recommended to ensure both healthy calcium uptake, and that the other cellular activates dependent on vitamin D can proceed normally.

Iron is the cofactor for CYP2R1 which requires its binding in order to function correctly. For those with the ‘G’ allele of A226-2810C, which is associated with reduced levels of circulating vitamin D, supplementation with iron may ensure that CYP2R1 is functioning properly, although the importance of this SNP in bone health and other cellular functions is likely minor ¹⁰.

When vitamin D binds to VDR it enables uptake of calcium from the gut. Whilst, calcium is not typically limited in the normal diet those pursuing a vegan, or dairy free diet may consider supplementation, especially if they carry the ‘G’ allele of A226-2810C ¹¹.

CYP2R1 an enzyme which converts vitamin D, either from the diet or that generated in the skin, into its circulating form calcifediol, which can in turn be converted into the bioactive form calcitriol. For those with the ‘G’ allele of T-1559C, which is associated with reduced levels of circulating vitamin D, supplementation with calcitriol may help ensure that appropriate vitamin D levels are maintained ensuring proper calcium uptake to maintain bone health and ensure normal cellular function ¹⁶.

The ‘G’ allele of T-1559C has not been associated with poor health outcomes; however, given that the majority of us are vitamin D deficient supplementation is to be recommended to ensure both healthy calcium uptake and vitamin D activity.

CYP2R1 requires iron as a cofactor in order to function correctly. For those with the ‘G’ allele of T-1559C, which is associated with reduced levels of circulating vitamin D, supplementation with iron may ensure that CYP2R1 is functioning correctly, although the exact importance of this SNP in bone health and other cellular functions is likely small ¹⁰.

A major function of vitamin D binding to VDR is to ensure proper uptake of calcium from the gut. Whilst, calcium is not typically limited in the normal diet those pursuing a vegan, or dairy free diet may consider supplementation, especially if they carry the ‘G’ allele of T-1559C ¹¹.