LDLR
Low density lipoprotein receptor (LDLR) binds circulating low density lipoproteins (LDL) and is encoded for by the LDLR gene. LDLR internalizes cholesterol-rich LDL into cells and thus maintains the plasma level of LDL, and is most active in the liver 1.
LDL 2, other lipoproteins, cholesterol and lipids are of great interest as they play a major role in the development of several cardiovascular disorders such as high blood pressure, stroke and heart attack risk. However, the exact role of lipoproteins, cholesterol and lipids in these disorders is currently under debate, making exact interpretation difficult 3.
There is one SNP of interest in the LDLR gene, rs6511720 or G67+2015T which is associated with altered circulating LDL levels, and potentially cardiovascular disease (CVD) risk.
Risk Description
The ‘T’ allele of G67+2015T in the LDLR gene is associated with lower levels of circulating LDL cholesterol and therefore a reduced CVD risk 3. However, given the ongoing research into the relative importance of cholesterol, lipids and cholesterol ratios it is currently unclear if this reduction in LDL is beneficial to all.
Whether or not G67+2015T is itself modulates LDLR activity or acts as a marker for some other mechanism remains unknown, although the authors present some preliminary evidence to suggest that LDLR expression is elevated in those carrying the ‘T’ allele.
As such, we currently feel unable to provide direct nutritional advice for this SNP. Rather this SNP should inform your dietary choices based on your current blood lipid results.
Discuss this information with your doctor before taking any course of action.